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KMID : 0358219940210010083
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Korean Journal of Fertility and Sterility
1994 Volume.21 No. 1 p.83 ~ p.88
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Insulin Resistance in Obese and Non-obese Patients with Polycystic Ovarian Syndrome
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임영구
이병석/조은정/차동현/박원일/박기현/조동제/이국/송찬호
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Abstract
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The study was designed to investigate the relationship between insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome (PCO). Twenty-two women with PCO, of whom thirteen were non-obese with body mass index (BMI, kg/m*)
of
<25
and nine were obese with BMI≥25 were studied. Eight non-obese control women and seven obese control women were studied. Serum concentrations of testosterone, lutenizing hormone (LH)/follicle-stimulating hormone (FSH) ratio, and insulin-like
growth
factor I (IGF-I) were found to be significantly higher (P<0.05) in PCO women compared with control women, which clearly is not related to obesity. Serum glucose, insulin, and C-peptide levels were measured during a 2-hour oral glucose tolerance
test
(OGTT). Non-obese and obese women with PCO both (P<0.05) compared with control women demonstrated significant hyperinsulinemia after OGTT. The degree of hyperinsulinemia was found to be significantly higher in the obese women with PCO compared
with
the
non-obese women with PCO.
We concluded that obesity may contribute to hyperinsulinemia, however may not play a central role in the pathogenesis of PCO.
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KEYWORD
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